Brand Name and Generic
Biaxin is the brand name for the generic antibiotic known as clarithromycin. It is classified as a macrolide antibiotic.
Therapeutic Indications
Biaxin is indicated for the treatment of various types of bacterial infections affecting the skin and respiratory system. Additionally, it is used in combination with other medications to treat stomach ulcers caused by Helicobacter pylori.
Available Dosage Forms
This medication is available in tablet form, extended-release tablet form, and as an oral suspension. The strength of Biaxin tablets typically ranges from 250 mg to 500 mg, while Biaxin XL, the extended-release version, is usually 500 mg.
Pharmacological Mechanism
Biaxin works by inhibiting the protein synthesis of bacteria, which is essential for their growth and replication. By binding to the ribosomal subunits of the bacteria, it prevents the translocation of peptides, leading to bacterial cell death.
Dosing Instructions
The dosing of Biaxin is dependent on the infection being treated, patient age, kidney function, and treatment duration. Adults commonly receive 250-500 mg every 12 hours, whereas pediatric doses vary based on weight. For treatment involving H. pylori, Biaxin is typically prescribed in higher doses and taken alongside other medications.
Administration Guidelines
Biaxin tablets should be swallowed whole, without crushing or chewing, to maintain the integrity of the medication release mechanisms. The oral suspension should be shaken well before use, and accurately measured with a proper dosing syringe or cup.
Food Interactions
Taking Biaxin with food may reduce stomach upset, although it can be taken with or without food. However, Biaxin XL should be taken with food to enhance its absorption and effectiveness.
Duration of Treatment
The length of time for taking Biaxin is determined by the type of infection. Generally, treatment durations range from 7 to 14 days. For H. pylori infections, therapy typically extends to 10-14 days.
Storage Requirements
Store Biaxin tablets at room temperature, away from moisture and heat. The oral suspension should be refrigerated and discarded after 14 days if any remains unused.
Drug Interactions
Biaxin should be used cautiously with certain medications due to potential drug interactions. Key interactions include effects on the metabolism of drugs like warfarin, theophylline, and carbamazepine, which can lead to increased plasma concentrations and potential toxicity.
Specific Populations
Adjustments in dosing may be necessary for patients with renal impairment, and caution is advised when prescribing Biaxin to these individuals. For pregnant or breastfeeding women, Biaxin should only be used if the benefit justifies the potential risk to the fetus or child.
Side Effect Profile
Potential side effects of Biaxin include gastrointestinal disturbances such as nausea, vomiting, abdominal pain, and diarrhea. It may also cause taste disturbances, headache, and, less commonly, abnormal liver function tests.
Monitoring Requirements
Patients taking Biaxin for an extended period should have periodic assessment of renal, hepatic, and hematopoietic function. Monitoring for signs of an antibiotic-associated colitis is also recommended during treatment.
Overdose Management
In the event of a suspected overdose, seek immediate medical attention. Symptoms may include vomiting, abdominal pain, and diarrhea. Treatment is symptomatic and supportive.
Pharmaceutical Contact Information
For any medication-related inquiries or adverse event reports, healthcare professionals can contact the pharmaceutical manufacturer via their medical information line or through the FDA’s MedWatch program.
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