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EFHSS Questions and Answers - Question Q00654

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EFHSS - Questions & Answers - Testing - Q00654
Endotoxin Pyrogen

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From: (Switzerland) Date: 31 October 2004, 14:05 [GMT]
Subject: Endotoxin Pyrogen

Is there any possibility to transfer Endotoxine to the packed products during ETO sterilization process? And is it commune to use filters for the water used during the preconditioning and conditioning?
Thanks,
Sean

From: Samir Qammaz (Jordan) Date: 2 April 2005, 09:18 [GMT]
Subject: Re: Endotoxin Pyrogen

Hi Ghaforian
since endotoxines are by-products of sterilisation procedure (cell wall fragments) SO ITS CANNOT BE FOUNDED ON A WELL PACKAGED, MICRO-ORGANISM -FREE MEDICAL DEVICE. USING FILTERS CAN DO NOTHING because endotoxin are water soluple proteins.

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